The BAF complex in development and disease

The BAF complex in development and disease

Blog Article

Abstract The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation.In the course of evolution from yeast to mammals, the BAF complex evolved an immense complexity with Insulated Bottle Holder a high number of subunits encoded by gene families.In this way, tissue-specific BAF function and regulation of development begin with the combinatorial assembly of distinct BAF complexes such as esBAF, npBAF and nBAF.

Furthermore, whole-genome sequencing reveals the tremendous role BAF complex mutations have in both neurodevelopmental disorders and human malignancies.Therefore, gaining a more elaborate insight into how BAF complex assembly influences its function and which ARNICA SKIN CREAM role distinct subunits play, will hopefully give rise to a better understanding of disease pathogenesis and ultimately to new treatments for many human diseases.